"Xiao Zhao, how is the patient's condition at the moment?"

Zhao Heng had just sat down when Dean Liu Shangming couldn't help but ask. Originally, he also wanted to call Zhao Heng over to inquire about the patient's situation.

Right after the conclusion of the minimally invasive biopsy and confirmation of the infection, he immediately reported this infection case to the department. The department also took it very seriously and promptly formed a task force to handle this public health emergency.

However, despite the attention from the department, things weren't easy for Liu Shangming. After all, it's the "Brain-Eating Amoeba," infamous in the field of infectious epidemics. Treating such a highly lethal parasitic infection is currently the biggest challenge.

"The patient's vital signs are relatively stable, but there is intense activity in the cerebral cortex."

Zhao Heng reported.

"Intense activity in the cerebral cortex? This indicates that the parasitic Fusarium in the patient's brain has reached its peak reproduction phase."

Upon hearing Zhao Heng's report on the infection, Liu Shangming, who was very experienced and knowledgeable, immediately realized that the parasite in the patient's brain had entered its reproductive peak.

If there is no effective way to inhibit the reproduction of the parasites in the patient's brain, then with the next substantial growth of the parasites, the patient's brain swelling will further worsen. This is a step-by-step process leading to death.

"What is the current treatment plan for the patient?"

Liu Shangming asked again.

"We have been using dehydration agents combined with Nimodipine, conducting mild hypothermia treatment, and administering Amphotericin B combination for antibiotics."

Zhao Heng stated the current treatment plan.

"This treatment plan is quite comprehensive, the best we can do in the current situation, yet it still can't suppress the reproduction of the parasites in the patient's brain; this time it's a complex situation."

Dean Liu Shangming thought for a moment and said.

In this setting, both Gao Jun and Zhao Heng can be considered insiders, so Dean Liu Shangming was straightforward in his speech, with nothing to hide.

"Xiao Zhao, just do your best. There have been 10 cases of Fusarium infection reported domestically, and without exception, all ten patients have died, so you shouldn't feel too pressured."

Gao Jun feared Zhao Heng was under too much pressure and said to him.

Doctors aren't omnipotent; there are still many diseases in the world that modern medicine can't cure or even understand the pathogenesis of.

So when facing difficult-to-treat diseases, it really tests the psychological resilience of doctors.

In Gao Jun's view, especially a genius like Zhao Heng is more prone to be affected, possibly causing psychological shadows and impacting future professional growth.

After hearing Gao Jun's words, Liu Shangming nodded slightly. Some situations are beyond human control; doctors aren't gods or omnipotent.

Moreover, the hospital must also prepare contingency plans for various possible scenarios.

"Dean, teacher, regarding this patient infected with Fusarium, I have made a discovery."

Seeing Dean Liu Shangming and Teacher Gao Jun considering his wellbeing, Zhao Heng felt a warmth in his heart and after thinking for a while, spoke.

A mentor cares for and nurtures students and subordinates, so naturally, as a student, he should also give his all.

"Well, let's hear it."

Dean Liu Shangming's eyes lit up upon hearing Zhao Heng's words. Lately, among young doctors, Zhao Heng attracted the most of his attention.

This young doctor always seems to surprise, as if miracles frequently happen around him, which is quite remarkable in young doctors.

"Dean, I came across a case where a patient infected with Fusarium survived after treatment abroad. I found that this patient had early-stage skin cancer, so the attending physician kept administering Mitifoxin. After the Fusarium infection diagnosis, the physician noted Mitifoxin seemed to have some effect in treating the Fusarium infection. Furthermore, the patient was in the early infection stage, making it one of the rare cured cases."

Zhao Heng organized his words and said.

"Mitifoxin? As an alkylphosphocholine drug, Mitifoxin indeed has some active effects on various parasites. Its main mechanism is inhibiting the PI3K/Akt survival pathway in the patient's body. Additionally, it can inhibit anti-Ige induced histamine release from human skin mast cells, reduce cytokines IL-1β, IL-4, and IL-6 in skin tissue cells, and strongly inhibit cholesterol esterification reaction."

When it comes to anti-cancer drugs, as an oncology department head and an absolute authority in domestic oncology treatment, Liu Shangming was as familiar as he could get.

"It's certainly a good attempt. Currently, not only us but also more than 10 infection cases have been reported in Country H, and the treatment effects are not very promising."

Gao Jun nodded in agreement.

Zhao Heng never disappoints him. Perhaps in terms of knowledge and professional quality, someone can match Zhao Heng, but in clinical thinking, Zhao Heng is the most open-minded person Gao Jun has ever seen.

An open clinical mind is of utmost importance to a doctor.

"Xiao Zhao, explain your thoughts in detail."

Liu Shangming pondered for a moment and asked Zhao Heng.

When Zhao Heng mentioned Mitifoxin, a treatment plan came to his mind, but he still wanted to hear Zhao Heng's thoughts, which also aimed to give a chance to young talent.

If Zhao Heng hadn't mentioned Mitifoxin, he would have never thought that a cancer treatment drug could be used to treat a Fusarium infection.

"Dean, the molecular weight of Mitifoxin is 407.57, which classifies it as a small molecule substance. Therefore, I think that on the basis of traditional administration, we could use a nanomedicine delivery method to achieve faster efficacy. The patient's situation is critical, and the faster the drug takes effect, the higher the chance of survival."

Zhao Heng thought about it and said. When he realized Mitifoxin might be effective for Fusarium infection, he considered Professor Li Hongwei's research project on nanotherapy at the Yanjing University School of Life Sciences.

This nanotherapy, in simple terms, involves enhancing the bioavailability and delaying the metabolic activity of therapeutic drugs using nanoparticles.

For instance, carbon nanotubes, polymer nanoparticles, dendrimers, etc., can be used to improve the pharmacokinetics of drug molecules by using nanoparticles or unique performance nanomaterials, forming a new drug delivery system based on nanomedicine.

Furthermore, in the field of nanotherapy, Professor Li Hongwei from Yanjing University School of Life Sciences is at the forefront.

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